CHPPC联合静脉化疗对老年进展期胃癌患者血清OPN、nm23H1蛋白表达的影响

　　[摘要] 目的 分析循環腹腔热灌注化疗（CHPPC）联合静脉化疗对老年胃癌患者治疗的临床效果及对患者血清骨桥蛋白（OPN）、nm23H1蛋白表达的影响。 方法 选取2016年1月～2017年1月河北北方学院附属第一医院收治的80例老年胃癌患者，并采用随机信封法分为观察组和对照组，每组40例。对照组采用常规静脉化疗方案进行治疗，观察组采用CHPPC联合静脉化疗方案进行治疗，在治疗结束8周后对治疗短期效果进行评估，并比较两组血清中癌胚抗原（CEA）、糖链抗原（CA242）、糖链抗原19-9（CA199）、OPN、nm23H1蛋白表达水平。 结果 治疗后，观察组治疗总有效率显著高于对照组，差异有高度统计学意义（P < 0.01）；治疗后，两组患者清中CEA、CA199及CA242水平均低于治疗前（P < 0.05），且观察组低于对照组（P < 0.05）；治疗后，两组患者血清中OPN水平低于治疗前（P < 0.05），nm23H1蛋白表达水平高于治疗前（P < 0.05），且观察组血清中OPN水平低于对照组（P < 0.05），nm23H1蛋白表达水平高于对照组（P < 0.05）。 结论 老年胃癌患者采用CHPPC联合静脉化疗方案治疗后可有效提高临床疗效，并改善血清中OPN及nm23H1水平，具有广泛临床意义。
　　[关键词] 循环腹腔热灌注化疗；静脉化疗；老年胃癌；骨桥蛋白；nm23H1
　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1673-7210（2018）02（c）-0171-04
　　[Abstract] Objective To analyze the effect of continuous hyperthermic peritoneal perfusion chemotherapy （CHPPC） combined with intravenous chemotherapy on the treatment of elderly patients with gastric cancer and the influence of expression of OPN and nm23H1 protein in the serum of the patients. Methods From January 2016 to January 2017， 80 elderly patients with gastric cancer in the First Affiliated Hospital of Hebei North University were selected， and divided into observation group and control group by random envelope method， with 40 cases in each group. The control group was treated with conventional intravenous chemotherapy， observation group was treated with CHPPC combined with intravenous chemotherapy， and the short-term efficacy of the treatment was evaluated 8 weeks after treatment， the serum CEA CA242， CA199， OPN， nm23H1 protein expression level between two groups were compared. Results After treatment， the total effective rate in observation group was higher than control group， the difference was highly statistically significant （P < 0.01）. After treatment， the serum CEA CA242， CA199 level of patients in both groups were lower than those before treatment （P < 0.05）， and observation group were lower than those control group （P < 0.05）. After treatment， the serum OPN level of patients in both groups was lower than before treatment （P < 0.05）， nm23H1 protein expression level was higher than before treatment （P < 0.05）， and the serum OPN level in the observation group was lower than control group （P < 0.05）， nm23H1 protein expression level was higher than control group （P < 0.05）. Conclusion Elderly patients with gastric cancer treated with CHPPC combined with intravenous chemotherapy can effectively improve the clinical efficacy and improve serum OPN and nm23H1 levels， and it has extensive clinical significance.

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